4ad6

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Template:STRUCTURE 4ad6

Synthesis and SAR of guanine based analogues for HPPK inhibitors

Template:ABSTRACT PUBMED 23565155

About this Structure

4ad6 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Chhabra S, Barlow N, Dolezal O, Hattarki MK, Newman J, Peat TS, Graham B, Swarbrick JD. Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK. PLoS One. 2013;8(4):e59535. doi: 10.1371/journal.pone.0059535. Epub 2013 Apr 2. PMID:23565155 doi:http://dx.doi.org/10.1371/journal.pone.0059535

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