2r0k

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Template:STRUCTURE 2r0k

Contents 1 Protease domain of HGFA with inhibitor Fab58 2 Function 3 About this Structure 4 See Also 5 Reference

Protease domain of HGFA with inhibitor Fab58

Template:ABSTRACT PUBMED 18077410

Function

[HGFA_HUMAN] Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.

About this Structure

2r0k is a 3 chain structure with sequence from [1] and Human. Full crystallographic information is available from OCA.

See Also

• Antibody

Reference

• Wu Y, Eigenbrot C, Liang WC, Stawicki S, Shia S, Fan B, Ganesan R, Lipari MT, Kirchhofer D. Structural insight into distinct mechanisms of protease inhibition by antibodies. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19784-9. Epub 2007 Dec 5. PMID:18077410