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2ync

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Template:STRUCTURE 2ync

Contents

Plasmodium vivax N-myristoyltransferase in complex with YnC12-CoA thioester.

Template:ABSTRACT PUBMED 24451586

Function

[A5K1A2_PLAVS] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586]

About this Structure

2ync is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

  • Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, Wilkinson AJ, Holder AA, Tate EW. Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach. Nat Chem. 2014 Feb;6(2):112-21. doi: 10.1038/nchem.1830. Epub 2013 Dec 22. PMID:24451586 doi:http://dx.doi.org/10.1038/nchem.1830

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OCA

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