4lzb

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Template:STRUCTURE 4lzb

Contents

Uracil binding pocket in Vaccinia virus uracil DNA glycosylase

Template:ABSTRACT PUBMED 24316823

Function

[UNG_VACCA] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Also part of a heterodimeric processivity factor which potentiates the DNA polymerase activity. Binds to DNA.

About this Structure

4lzb is a 12 chain structure. Full crystallographic information is available from OCA.

Reference

  • Schormann N, Banerjee S, Ricciardi R, Chattopadhyay D. Structure of the uracil complex of Vaccinia virus uracil DNA glycosylase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Dec;69(Pt 12):1328-34., doi: 10.1107/S1744309113030613. Epub 2013 Nov 28. PMID:24316823 doi:http://dx.doi.org/10.1107/S1744309113030613

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