4g09

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Template:STRUCTURE 4g09

Contents

The crystal structure of the C366S mutant of HDH from Brucella suis in complex with a substituted benzyl ketone

Template:ABSTRACT PUBMED 24140957

Function

[HISX_BRUSU] Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine (By similarity).

About this Structure

4g09 is a 1 chain structure with sequence from Brusu. Full crystallographic information is available from OCA.

Reference

  • D'ambrosio K, Lopez M, Dathan NA, Ouahrani-Bettache S, Kohler S, Ascione G, Monti SM, Winum JY, De Simone G. Structural basis for the rational design of new anti-Brucella agents: The crystal structure of the C366S mutant of l-histidinol dehydrogenase from Brucella suis. Biochimie. 2013 Oct 17. pii: S0300-9084(13)00349-0. doi:, 10.1016/j.biochi.2013.09.028. PMID:24140957 doi:http://dx.doi.org/10.1016/j.biochi.2013.09.028

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