4jup

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Template:STRUCTURE 4jup

Contents

Dimeric structure of CARMA1 CARD

Template:ABSTRACT PUBMED 24224005

Disease

[CAR11_HUMAN] Persistent polyclonal B-cell lymphocytosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

[CAR11_HUMAN] Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.

About this Structure

4jup is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Jang TH, Park JH, Park HH. Novel disulfide bond-mediated dimerization of the CARD domain was revealed by the crystal structure of CARMA1 CARD. PLoS One. 2013 Nov 5;8(11):e79778. doi: 10.1371/journal.pone.0079778. eCollection, 2013. PMID:24224005 doi:http://dx.doi.org/10.1371/journal.pone.0079778

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