4nuv
From Proteopedia
Contents |
Heterotetramer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)
Template:ABSTRACT PUBMED 24415938
Function
[PVDR_PLAVS] Binds to the human erythrocytes Duffy blood group determinant. [ACKR1_HUMAN] Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
About this Structure
4nuv is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- Batchelor JD, Malpede BM, Omattage NS, Dekoster GT, Henzler-Wildman KA, Tolia NH. Red Blood Cell Invasion by Plasmodium vivax: Structural Basis for DBP Engagement of DARC. PLoS Pathog. 2014 Jan;10(1):e1003869. doi: 10.1371/journal.ppat.1003869. Epub, 2014 Jan 9. PMID:24415938 doi:http://dx.doi.org/10.1371/journal.ppat.1003869
