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4kxl

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Template:STRUCTURE 4kxl

Contents

Crystal structure of DNPH1 (RCL) with 6-CYCLOPENTYL-AMP

Template:ABSTRACT PUBMED 24260472

Function

[DNPH1_RAT] Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.[1]

About this Structure

4kxl is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Amiable C, Pochet S, Padilla A, Labesse G, Kaminski PA. N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1. PLoS One. 2013 Nov 19;8(11):e80755. doi: 10.1371/journal.pone.0080755., eCollection 2013. PMID:24260472 doi:http://dx.doi.org/10.1371/journal.pone.0080755
  1. ↑ Ghiorghi YK, Zeller KI, Dang CV, Kaminski PA. The c-Myc target gene Rcl (C6orf108) encodes a novel enzyme, deoxynucleoside 5'-monophosphate N-glycosidase. J Biol Chem. 2007 Mar 16;282(11):8150-6. Epub 2007 Jan 18. PMID:17234634 doi:http://dx.doi.org/10.1074/jbc.M610648200

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