3lja
From Proteopedia
Contents |
Using Soft X-Rays for a Detailed Picture of Divalent Metal Binding in the Nucleosome
Template:ABSTRACT PUBMED 20350553
Function
[H2B11_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [H4_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
About this Structure
3lja is a 10 chain structure with sequence from African clawed frog. Full crystallographic information is available from OCA.
See Also
Reference
- Wu B, Davey CA. Using soft X-rays for a detailed picture of divalent metal binding in the nucleosome. J Mol Biol. 2010 May 21;398(5):633-40. Epub 2010 Mar 27. PMID:20350553 doi:10.1016/j.jmb.2010.03.038
