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4lsd

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Template:STRUCTURE 4lsd

Contents

Myokine structure

Template:ABSTRACT PUBMED 24114836

Function

[FNDC5_HUMAN] Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA (By similarity).

About this Structure

4lsd is a 8 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Schumacher MA, Chinnam N, Ohashi T, Shah RS, Erickson H. Structure of irisin reveals a novel intersubunit beta-sheet fibronectin (FNIII) dimer; implications for receptor activation. J Biol Chem. 2013 Oct 10. PMID:24114836 doi:http://dx.doi.org/10.1074/jbc.M113.516641

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