3loj

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Template:STRUCTURE 3loj

Contents

Structure of Mycobacterium tuberculosis dUTPase H145A mutant

Template:ABSTRACT PUBMED 20601405

Function

[DUT_MYCTU] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116]

About this Structure

3loj is a 1 chain structure with sequence from "bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884. Full crystallographic information is available from OCA.

See Also

Reference

  • Pecsi I, Leveles I, Harmat V, Vertessy BG, Toth J. Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase. Nucleic Acids Res. 2010 Jul 2. PMID:20601405 doi:10.1093/nar/gkq584

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