1h1d

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Template:STRUCTURE 1h1d

Contents

CATECHOL O-METHYLTRANSFERASE

Template:ABSTRACT PUBMED 12237326

Function

[COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

About this Structure

1h1d is a 1 chain structure with sequence from Buffalo rat. Full crystallographic information is available from OCA.

See Also

Reference

  • Bonifacio MJ, Archer M, Rodrigues ML, Matias PM, Learmonth DA, Carrondo MA, Soares-Da-Silva P. Kinetics and crystal structure of catechol-o-methyltransferase complex with co-substrate and a novel inhibitor with potential therapeutic application. Mol Pharmacol. 2002 Oct;62(4):795-805. PMID:12237326

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