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4n9d
From Proteopedia
Contents |
Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
Template:ABSTRACT PUBMED 24433859
Function
[NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
About this Structure
4n9d is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Dragovich PS, Zhao G, Baumeister T, Bravo B, Giannetti AM, Ho YC, Hua R, Li G, Liang X, Ma X, O'Brien T, Oh A, Skelton NJ, Wang C, Wang W, Wang Y, Xiao Y, Yuen PW, Zak M, Zhao Q, Zheng X. Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett. 2014 Feb 1;24(3):954-62. doi: 10.1016/j.bmcl.2013.12.062., Epub 2013 Dec 21. PMID:24433859 doi:http://dx.doi.org/10.1016/j.bmcl.2013.12.062
Categories: Nicotinamide phosphoribosyltransferase | Baumeister, T. | Bravo, B. | Brien, T O. | Dragovich, P S. | Giannetti, A M. | Ho, Y. | Hua, R. | Li, G. | Liang, X. | Oh, A. | Skelton, N J. | Wang, C. | Wang, W. | Wang, Y. | Xiao, Y. | Yuen, P. | Zak, M. | Zhao, G. | Zhao, Q. | Zheng, X. | Transferase-transferase inhibitor complex
