4c0h

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Template:STRUCTURE 4c0h

Contents 1 Extended interface between Pcf11p and Clp1p and structural basis for ATP loss in Gly135Arg point mutant 2 Function 3 About this Structure 4 Reference

Extended interface between Pcf11p and Clp1p and structural basis for ATP loss in Gly135Arg point mutant

Template:ABSTRACT PUBMED 24508575

Function

[CLP1_YEAST] Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with the cleavage factor NAB4/CFIB and the cleavage and polyadenylation factor (CPF) complex.^[1]

About this Structure

4c0h is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

• Dupin AF, Fribourg S. Structural basis for ATP loss by Clp1p in a G135R mutant protein. Biochimie. 2014 Feb 5. pii: S0300-9084(14)00035-2. doi:, 10.1016/j.biochi.2014.01.017. PMID:24508575 doi:http://dx.doi.org/10.1016/j.biochi.2014.01.017

1. ↑ Gross S, Moore C. Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6080-5. Epub 2001 May 8. PMID:11344258 doi:http://dx.doi.org/10.1073/pnas.101046598