4cft

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Template:STRUCTURE 4cft

Contents

Structure of bovine endothelial nitric oxide synthase heme domain in complex with 7-((3-Fluorophenethylamino)ethyl)quinolin-2-amine

Template:ABSTRACT PUBMED 24472039

Function

[NOS3_BOVIN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

About this Structure

4cft is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Cinelli MA, Li H, Chreifi G, Martasek P, Roman LJ, Poulos TL, Silverman RB. Simplified 2-Aminoquinoline-Based Scaffold for Potent and Selective Neuronal Nitric Oxide Synthase Inhibition. J Med Chem. 2014 Feb 10. PMID:24472039 doi:http://dx.doi.org/10.1021/jm401838x

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OCA

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