Deaminase

Deaminase removes an amine group from a molecule. Cytosine deaminase (CDDA) converts cytosine to uracil. Cytidine deaminase (CDDA) converts cytidine to uridine. 5-methylcytosine deaminase (MCDA) produces thymine. Guanine deaminase (GDA) converts guanine to xanthine. Adenine deaminase (ADA) converts adenine to hypoxanthine.

3D Structures of deaminase

Updated on 24-February-2014

Cytidine deaminase

1r5t – yCDA - yeast

2a8n – AtCDA – Agrobacterium tumefaciens
2g84 – CDA – Nitrosomonas europaea
2d30 – CDA – Bacillus anthracis
3dmo – CDA – Burkholderia pseudomallei
3ijf – CDA – Mycobacterium tuberculosis
3mpz – CDA – Mycobacterium smegmatis
3r2n – CDA – Mycobacterium leprae
4f3w – CDA – Mycobacterium marinum

Cytidine deaminase complex with nucleoside

1ctt – EcCDA + dihydro-pyrimidinone – Escherichia coli

1ctu – EcCDA + hydroxyl-dihydro-zebularine
1af2 – EcCDA + uridine
1aln – EcCDA + deazacytidine
1jtk – BsCDA + tetrahydrodeoxyuridine - Bacillus subtilis
1uwz, 1ux0, 1ux1 – BsCDA (mutant) + tetrahydrodeoxyuridine
1mq0 – hCDA + β-ribofuranosyl diazepinone - human
1zab – mCDA + deazauridine - mouse
2fr5 – mCDA + tetrahydrouridine
2fr6 – mCDA + cytidine + uridine
4eg2 – CDA + uridine - Vibrio cholerae

Cytosine deaminase

1k6w – EcCDDA

1r9x, 1r9y, 1r9z, 1ra0, 1ra5, 3g77 – EcCDDA (mutant)
1rb7, 1uaq – yCDDA
1ysb, 1ysd – yCDDA (mutant)

Cytosine deaminase complex

3r0d – EcCDDA + Zn

3rn6 – EcCDDA + Zn + iso-guanine
1k70 – EcCDDA + pyrimidine derivative
1rak – EcCDDA (mutant) + pyrimidine derivative
3o7u – EcCDDA + Zn + phosphono-cytosine
1ox7 – yCDDA + Zn
1p6o – yCDDA + pyrimidine derivative
2o3k – yCDDA (mutant) + pyrimidine derivative

Guanine deaminase

1tiy, 1wkq – BsGDA

3e0l – hGDA

Guanine deaminase complex with nucleoside

2i9u – GDA + guanine – Clostridium acetobutylicum

2ood – GDA + guanine – Bradrhizobium japonicum
2uz9 – hGDA + xanthine
4aql – hGDA + valacyclovir

Adenine deaminase

2ics – ADA - Enterococcus faecalis

3nqb, 3t81, 3t8l – AtADA
3ou8 – PaADA – Pseudomonas aeruginosa

Adenine deaminase complex with nucleoside

3pan – PaADA + hypoxanthine

3pao – PaADA + adenine
3pbm – PaADA + chloropurine
3rys – ADA + adenine – Arthrobacter aurescens