Enoylpyruvate transferase (MurA) catalyzes the ligation of phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine (UNAG). The pyruvate moiety makes the linker between the glycan and peptide portion of peptidoglycans. Thus MurA is essential for the biosynthesis of bacterial cell walls and is a target for antibiotics. MurA is composed of catalytic domain and C-terminal domain.
3D Structures of enoylpyruvate transferase
Updated on 02-March-2014
1naw, 1ejc, 1ejd – EncMurA – Enterobacter cloacae
1dlg, 3spb, 3v5v, 4e7g, 4eii – EncMurA (mutant)
1uae – EcMurA – Escherichia coli
2yvw – AaMurA – Aquifex aeolicus
3zh3, 3zh4 – MurA – Streptococcus pneumoniae
3r38 – MurA – Listeria monocytogenes
3sg1 – MurA – Bacillus anthracis
MurA binary complex
1a2n – EcMurA (mutant) + reaction intermediate
3iss – EcMurA (mutant) + enoylpyruvyl-UNAG
1eyn – EncMurA (mutant) + aniline-naphthalene sulfonate
4e7b – EncMurA + UDP-glucose
4e7e – EncMurA (mutant) + UDP-glucose
4e7c – EncMurA + UTP
4e7d – EncMurA + UDP
4e7f – EncMurA (mutant) + UDP
1q3g – EncMurA (mutant) + reaction intermediate
2rl1 – HiMurA + UNAG – Haemophilus influenzae
3kqj – EcMurA + UNAG
3upk – EncMurA + UNAG
1ybg – EcMurA (mutant) + inhibitor
3kqa – EncMurA + terreic acid inhibitor
3swq – EncMurA (mutant) + enoylpyruvyl-UNAG
3v4t, 1ryw – EncMurA (mutant) + UNAG
MurA ternary complex with antibiotics
3kr6 – EcMurA + UNAG + fosfomycin
3lth – EncMurA + UNAG + fosfomycin
3vcy – MurA + UNAG + fosfomycin – Vibrio fischeri
2rl2 – HiMurA + UNAG + fosfomycin
2z2c – EcMurA + UNAG + cnicin
MurA ternary complex with PEP
3su9, 3swa, 3swi – EncMurA (mutant) + UNAG + PEP
3swd – EcMurA (mutant) + UNAG + PEP
3swe – HiMurA (mutant) + UNAG + PEP
3swg – AaMurA + UNAG + PEP
