4bwl

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Template:STRUCTURE 4bwl

Contents

Structure of the Y137A mutant of E. coli N-acetylneuraminic acid lyase in complex with pyruvate, N-acetyl-D-mannosamine and N- acetylneuraminic acid

Template:ABSTRACT PUBMED 24521460

Function

[NANA_ECOLI] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate.[HAMAP-Rule:MF_01237]

About this Structure

4bwl is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Daniels AD, Campeotto I, van der Kamp MW, Bolt AH, Trinh CH, Phillips SE, Pearson AR, Nelson A, Mulholland AJ, Berry A. Reaction Mechanism of N-Acetylneuraminic Acid Lyase Revealed by a Combination of Crystallography, QM/MM Simulation, and Mutagenesis. ACS Chem Biol. 2014 Feb 21. PMID:24521460 doi:http://dx.doi.org/10.1021/cb500067z

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