4lzj

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Template:STRUCTURE 4lzj

Contents

Crystal Structure of MurQ from H.influenzae with bound inhibitor

Template:ABSTRACT PUBMED 24251551

Function

[MURQ_HAEIN] Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity).

About this Structure

4lzj is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Hadi T, Hazra S, Tanner ME, Blanchard JS. Structure of MurNAc 6-phosphate hydrolase (MurQ) from Haemophilus influenzae with a bound inhibitor. Biochemistry. 2013 Dec 23;52(51):9358-66. doi: 10.1021/bi4010446. Epub 2013 Nov, 22. PMID:24251551 doi:http://dx.doi.org/10.1021/bi4010446

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