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4llk

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Template:STRUCTURE 4llk

Contents

Crystal structure of PDE10A2 with fragment ZT217

Template:ABSTRACT PUBMED 24375910

Function

[PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.[1]

About this Structure

4llk is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Recht MI, Sridhar V, Badger J, Bounaud PY, Logan C, Chie-Leon B, Nienaber V, Torres FE. Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography. J Biomol Screen. 2013 Dec 27. PMID:24375910 doi:http://dx.doi.org/10.1177/1087057113516493
  1. ↑ Wang H, Liu Y, Hou J, Zheng M, Robinson H, Ke H. Structural insight into substrate specificity of phosphodiesterase 10. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5782-7. Epub 2007 Mar 26. PMID:17389385

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