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4isy

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Template:STRUCTURE 4isy

Contents

Crystal structure of IscS from Mycobacterium tuberculosis

Template:ABSTRACT PUBMED 24548275

Function

[ISCS_MYCTU] Catalyzes the removal of elemental sulfur from cysteine to produce alanine (Probable). Participates in the biosynthesis of metalloclusters by providing the inorganic sulfur required for Fe-S core formation. One acceptor is Whib3, on which this enzyme assembles a 4Fe-4S cluster.

About this Structure

4isy is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Rybniker J, Pojer F, Marienhagen J, Kolly GS, Chen JM, van Gumpel E, Hartmann P, Cole ST. The cysteine desulfurase IscS of Mycobacterium tuberculosis is involved in iron-sulfur cluster biogenesis and oxidative stress defense. Biochem J. 2014 Feb 19. PMID:24548275 doi:http://dx.doi.org/10.1042/BJ20130732

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