4irb

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Template:STRUCTURE 4irb

Contents

Crystal Structure of Vaccinia Virus Uracil DNA Glycosylase Mutant del171-172D4

Template:ABSTRACT PUBMED 23519808

Function

[UNG_VACCA] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Also part of a heterodimeric processivity factor which potentiates the DNA polymerase activity. Binds to DNA.

About this Structure

4irb is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Sartmatova D, Nash T, Schormann N, Nuth M, Ricciardi R, Banerjee S, Chattopadhyay D. Crystallization and preliminary X-ray diffraction analysis of three recombinant mutants of Vaccinia virus uracil DNA glycosylase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Mar 1;69(Pt 3):295-301., doi: 10.1107/S1744309113002716. Epub 2013 Feb 23. PMID:23519808 doi:http://dx.doi.org/10.1107/S1744309113002716

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