426d

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Image:426d.gif

426d, resolution 3.0Å

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THE STRUCTURE OF MOST STUDIED DNA FRAGMENT CHANGES UNDER THE INFLUENCE OF IONS: A NEW PACKING OF D(CGCGAATTCGCG)

Overview

The title oligonucleotide and many related dodecamers have been extensively studied alone and as DNA-drug complexes. In practically all cases they were found to crystallize in the same space group, stabilized by interactions among the terminal guanine bases. Here we report new packing interactions (R3) in the presence of Ca2+. The oligonucleotides interact by placing their terminal guanines in the narrow groove of a neighbor molecule, an interaction which had never been found in dodecamers.

About this Structure

426D is a Protein complex structure of sequences from [1] with as ligand. Full crystallographic information is available from OCA.

Reference

The structure of the most studied DNA fragment changes under the influence of ions: a new packing of d(CGCGAATTCGCG)., Liu J, Malinina L, Huynh-Dinh T, Subirana JA, FEBS Lett. 1998 Nov 6;438(3):211-4. PMID:9827547

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