Glutaminase

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Glutaminase (GLN) catalyzes the conversion of glutamine (Gln) to glutamic acid (Glu). GLN is present at the axonal termini of neurons where GA functions as a neurotransmitter. ADP is an activator of GLN. GLN is a homodimer. In human GLN is found as 2 isozymes – GLN and GLN 2. Glutaminase-asparaginase (GLN-ASN) can amidohydrolase both glutamine and asparagine to their corresponding Glu and Asp.

1 3D structures of glutaminase

3D structures of glutaminase

Updated on 11-March-2014

GLN

3if5, 3ih8, 3ih9, 3agd – MlGLN – Micrococcus luteus
2pby – GLN – Geobacillus kaustophilus
2zk9 – CpGLN – Chryseobacterium proteolyticum
3a54, 3a55, 3a56 – CpGLN (mutant)
3agf - BsGLN – Bacillus subtilis
3ss3, 3ss4 – mGLN C – mouse
4jkt - mGLN kidney isoform
3voy – hGLN kidney isoform – human
4bqm - hGLN liver isoform

GLN complex

3brm – BsGLN + norleucine
3czd, 3unw – hGLN + Glu
3vp0 – hGLN + Gln
3uo9, 3voz, 3vp2, 3vp3, 3vp4 - hGLN + inhibitor
3iha, 3ihb, 3age - MlGLN + Glu
3ss5 – mGLN + Glu
3vp1 - hGLN + inhibitor + Glu