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3wj9
From Proteopedia
Contents |
Crystal structure of the eukaryotic initiation factor
Template:ABSTRACT PUBMED 24569939
Function
[EIF2A_SCHPO] Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins (By similarity).
About this Structure
3wj9 is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Kashiwagi K, Ito T, Yokoyama S. Crystal structure of the eukaryotic translation initiation factor 2A from Schizosaccharomyces pombe. J Struct Funct Genomics. 2014 Feb 26. PMID:24569939 doi:http://dx.doi.org/10.1007/s10969-014-9177-y
