1e6j

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Template:STRUCTURE 1e6j

Contents 1 Crystal structure of HIV-1 capsid protein (p24) in complex with Fab13B5 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal structure of HIV-1 capsid protein (p24) in complex with Fab13B5

Template:ABSTRACT PUBMED 11080628

Function

[GAG_HV1H2] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).

About this Structure

1e6j is a 3 chain structure with sequence from Hiv-1 and Mus musculus. Full crystallographic information is available from OCA.

See Also

• Virus coat protein

Reference

• Monaco-Malbet S, Berthet-Colominas C, Novelli A, Battai N, Piga N, Cheynet V, Mallet F, Cusack S. Mutual conformational adaptations in antigen and antibody upon complex formation between an Fab and HIV-1 capsid protein p24. Structure. 2000 Oct 15;8(10):1069-77. PMID:11080628