4nat

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Template:STRUCTURE 4nat

Contents

Inhibitors of 4-Phosphopanthetheine Adenylyltransferase

Template:ABSTRACT PUBMED 24041904

Function

[COAD_STAAW] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).

About this Structure

4nat is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

  • de Jonge BL, Walkup GK, Lahiri SD, Huynh H, Neckermann G, Utley L, Nash TJ, Brock J, San Martin M, Kutschke A, Johnstone M, Laganas V, Hajec L, Gu RF, Ni H, Chen B, Hutchings K, Holt E, McKinney D, Gao N, Livchak S, Thresher J. Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy. Antimicrob Agents Chemother. 2013 Dec;57(12):6005-15. doi: 10.1128/AAC.01661-13. , Epub 2013 Sep 16. PMID:24041904 doi:http://dx.doi.org/10.1128/AAC.01661-13

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