4m7u

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Template:STRUCTURE 4m7u

Contents

Dihydrofolate reductase from Enterococcus faecalis complexed with NADP(H)

Template:ABSTRACT PUBMED 24495113

Function

[Q834R2_ENTFA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]

About this Structure

4m7u is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Bourne CR, Wakeham N, Webb N, Nammalwar B, Bunce RA, Berlin KD, Barrow WW. The Structure and Competitive Substrate Inhibition of Dihydrofolate Reductase from Enterococcus faecalis Reveal Restrictions to Cofactor Docking. Biochemistry. 2014 Feb 25;53(7):1228-38. doi: 10.1021/bi401104t. Epub 2014 Feb, 11. PMID:24495113 doi:http://dx.doi.org/10.1021/bi401104t

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