1qs3

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Template:STRUCTURE 1qs3

Contents

NMR SOLUTION CONFORMATION OF AN ANTITOXIC ANALOG OF ALPHA-CONOTOXIN GI

Template:ABSTRACT PUBMED 10508392

Function

[CA1A_CONGE] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. The higher affinity site for alpha-conotoxin GI is the alpha/delta site on mouse muscle-derived BC3H-1 receptor, and the other site (alpha/gamma site) on nicotinic receptors from Torpedo californica electric organ.

About this Structure

1qs3 is a 1 chain structure. Full experimental information is available from OCA.

Reference

  • Mok KH, Han KH. NMR solution conformation of an antitoxic analogue of alpha-conotoxin GI: identification of a common nicotinic acetylcholine receptor alpha 1-subunit binding surface for small ligands and alpha-conotoxins. Biochemistry. 1999 Sep 14;38(37):11895-904. PMID:10508392

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