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4g6m

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Template:STRUCTURE 4g6m

Contents

Crystal strucure of human IL-1beta in complex with therapeutic antibody binding fragment of gevokizumab

Template:ABSTRACT PUBMED 23041424

Function

[IL1B_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.[1]

About this Structure

4g6m is a 3 chain structure with sequence from Human. Full crystallographic information is available from OCA.

See Also

Reference

  • Blech M, Peter D, Fischer P, Bauer MM, Hafner M, Zeeb M, Nar H. One Target-Two Different Binding Modes: Structural Insights into Gevokizumab and Canakinumab Interactions to Interleukin-1beta J Mol Biol. 2012 Oct 3. pii: S0022-2836(12)00786-3. doi:, 10.1016/j.jmb.2012.09.021. PMID:23041424 doi:10.1016/j.jmb.2012.09.021
  1. ↑ Van Damme J, De Ley M, Opdenakker G, Billiau A, De Somer P, Van Beeumen J. Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1. Nature. 1985 Mar 21-27;314(6008):266-8. PMID:3920526

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