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Interleukin
From Proteopedia
Template:STRUCTURE 2nvh
Interleukin (IL) is a cytokine which functions in the immune system. IL deficiency results in autoimmune disease. IL families are denoted by numbers.
- IL-1 is a group of 11 cytokines which regulate immune and inflammatory response. See Interleukin-1 beta.
- IL-2 is a cytokine made by leukocytes. It is used in cancer therapy to boost the immune system.
- IL-3 improves the body's natural response to disease by stimulating the differentiation of multipotent hematopoietic stem cells into myeloid or lymphoid progenitor cells.
- IL-4 induces the differentiation of naive helper T cells (Th0) to Th2 cells.
- IL-5 stimulates B cell growth and increases immunoglobulin secretion.
- IL-6 is both a pro-inflammatory cytokine and anti-inflammatory myokine.
- IL-7 is a cytokine important for B and T cells development.
- IL-8 induces chemotaxis and phagocytosis.
- IL-10 see Interleukin-10.
- IL-12 induces the differentiation of naive helper T cells (Th0) to Th1 cells.
- IL-13 induces the differentiation of naive helper T cells (Th0) to Th2 cells.
- IL-15 see Interleukin-15.
- IL-16 acts as chemoattractant, modulator of T cell activity and inhibitor of HIV replication.
- IL-17 recruits monocytes and neutrophils to the site of inflammation.
- IL-18 induces cell-mediated immunity following infection by microbial lipopolysaccharides.
- IL-19 induces activation of the signal transducer and activator of STAT3.
- IL-21 has potent effect on natural killer cells.
- IL-22 stimulates inflammatory responses like S100 and defensin.
- IL-23 induces activation of the signal transducer and activator of STAT4.
- IL-28 has a role in the immune defense against viruses.
- IL-29 similar to IL-28.
- IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines.
- IL-34 increases growth or survival of monocytes.
3D structures of interleukin
Updated on 19-March-2014
IL-1 α
2ila - hIL-1 α - human
2kki - hIL-1 α residues 121-271
2l5x – hIL-1 α residues 121-271 + calcium-binding protein A13 – NMR
IL-1 β
2wry - cIL-1 β – chicken
3nj5 – cIL-1 β (mutant)
2nvh, 9ilb, 1iob, 5i1b, 2i1b, 4i1b, 1i1b - hIL-1 β
1tp0, 1t4q, 1too, 1twe, 1twm, 1s0l, 1l2h, 1hib, 21bi, 31bi, 41bi - hIL-1 β (mutant)
6i1b, 7i1b - hIL-1 β - NMR
3ltq - hIL-1 β residues 117-269
3pok - hIL-1 β residues 117-269 (mutant)
1itb - hIL-1 β + IL-1 receptor 1 extracellular domain
3o4o - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein
4dep - hIL-1 β + IL-1 receptor 1 + IL-1 receptor accessory protein
4g6j, 4g6m - hIL-1 β + antibody
2kh2 - hIL-1 β + SCFV - NMR
1md6 – mIL-1F5 – mouse
2mib, 8i1b - mIL-1 β
IL-2 (T-cell growth factor)
1m47, 1m4c, 3ink – hIL-2
3qb1 - hIL-2 (mutant)
1irl – hIL-2 (mutant) - NMR
2erj, 2b5i - hIL-2 + IL-2 receptor α and β + cytokine receptor common γ
1z92 - hIL-2 + IL-2 receptor α
3qaz - hIL-2 + IL-2 receptor β and γ
1qvn, 1nbp, 1m4a, 1m4b – hIL-2 (mutant) + inhibitor
1pw6, 1py2, 1m48, 1m49 – hIL-2 + inhibitor
IL-3
1jli – hIL-3 (mutant) – NMR
2l3o – mIL-3 residues 33-156 (mutant) - NMR
IL-4
2b8u, 1hik, 2int, 1rcb – hIL-4
2cyk, 1cyl, 1itm, 1bbn, 1bcn, 1iti, 1itl – hIL-4 - NMR
2b8x, 2b8y, 2b8z, 2b90, 2b91, 2d48, 1hzi, 1hij - hIL-4 (mutant)
1iar - hIL-4 + IL-4 receptor α (mutant)
3bpl - hIL-4 + IL-4 receptor α + cytokine receptor common γ
3qb7 - hIL-4 + cytokine receptor common γ
3bpn - hIL-4 + IL-4 receptor α + IL-13 receptor α
IL-5
1hul – hIL-5
3b5k – mIL-5
3qt2 - hIL-5 + IL-5 receptor α (mutant)
3va2 - hIL-5 + IL-5 receptor α
IL-6
1alu – hIL-6
2l3y - mIL-6 residues 27-211 - NMR
1il6, 2il6 – hIL-6 - NMR
1p9m - hIL-6 + IL-6 receptor α and β
1i16 – IL-6 + IL-6 receptor β - Herpesvirus 8
4j4l – hIL-6 + internalin B
4ni7, 4ni9 – hIL-6 + nucleotide aptamer
IL-7
3di2, 3di3 - hIL-7 residues 26-177 + IL-7 receptor α ectodomain
IL-8
3il8 – hIL-8
1il8, 2il8 – hIL-8]- NMR
1qe6, 1icw – hIL-8 (mutant)
1ikl, 1ikm - hIL-8 (mutant) - NMR
1rod - hIL-8/melanoma growth stimulating protein – NMR
1ilp, 1ilq - hIL-8 + IL-8 receptor peptide
IL-10
2h24, 1inr, 2ilk, 1ilk – hIL-10
1j7v – hIL-10 + IL-10 receptor α (mutant)
1y6k - hIL-10 residues 19-178 + IL-10 receptor α
IL-10 viral
1vlk - hvIL-10 residues 26-170 - human herpesvirus 4
1y6m - hvIL-10 residues 26-170 + IL-10 receptor α
1y6n - hvIL-10 residues 26-170 (mutant) + IL-10 receptor α
1lqs - hvIL-10 residues 20-176 + IL-10 receptor α - human herpesvirus 5
1lk3 - hvIL-10 residues 26-175 + antibody
IL-12
1f45 - hIL-12 α and β (mutant)
1f42 - hIL-12 β P40 domain
3hmx - hIL-12 α and β+ antibody
3qwr - hIL-12 β + hIL- 23 α + adnectin
IL-13
1ijz, 1ik0 – hIL-13 – NMR
1ga3 - hIL-13 residues 21-132 - NMR
3l5w, 3l5x, 3l5y, 3g6d, 4i77, 4ps4 - hIL-13 residues 35-146 + antibody
3lb6 - hIL-13 + IL-13 receptor α2
3bpo - hIL-13 + IL-4 receptor α + IL-13 receptor α
IL-15
2xqb – hIL-15 + antibody
2psm, 2z3q, 2z3r - hIL-15 + IL-15 receptor α
4gs7 - hIL-15 + IL-15 receptor α + IL-2 receptor β,γ
IL-16
1i16 – hIL-16 - NMR
1x6d – hIL-16 PDZ domain – NMR
IL-17
4hr9 - hIL-17A (mutant)
4hsa - hIL-17A (mutant) + IL-17A receptor α
2vxs - hIL-17A residues 20-255 + antibody
1jpy – hIL-17F
3jvf - hIL-17F + IL-17 receptor α
IL-18 (Interferon-γ inducing factor)
1j0s – hIL-18 - NMR
4hjj - hIL-18 + antibody
2vxt - hIL-18 (mutant) + antibody
3f62 - hIL-18 residues 37-193 (mutant) + IL-18 binding protein
4eee, 4ekx - hIL-18 (mutant) + 14L protein
IL-19
1n1f – hIL-19
IL-20
4doh - hIL-20 + IL-20 receptor α,β
IL-21
2oqp– hIL-21 – NMR
3tgx - hIL-21 + IL-21 receptor α (mutant)
IL-22
1ykb, 1m4r – hIL-22
3g9v - hIL-22 residues 29-179 + IL-22 receptor α2
3dlq, 3dgc - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1
3q1s - hIL-22 residues 29-179 (mutant) + antibody
IL-23
3d87 - hIL-23 α
3d85 - hIL-23 α + antibody
4grw - hIL-23 α + + hIL-12 β + nanobody
3duh - hIL-23 α + hIL-12 β
IL-28
3hhc – hIL-28B
IL-29
3og4, 3og6 – hIL-29 + IL-28 receptor α
IL-33
2kll - hIL-33 residues 110-270 - NMR
IL-34
4dkc - hIL-34
4exn - mIL-34
4dkd - hIL-34 active core + macrophage colony-stimulating factor 1 receptor
4exp - mIL-34 active core + macrophage colony-stimulating factor 1 receptor
4dke, 4dkf - hIL-34 active core + antibody
