3whc

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Template:STRUCTURE 3whc

Contents

Crystal structure of a transcriptional regulator FadR from Bacillus subtilis in complex with stearoyl-CoA

Template:ABSTRACT PUBMED 24356978

Function

[FADR_BACSU] Transcriptional regulator in fatty acid degradation. Represses transcription of genes required for fatty acid transport and beta-oxidation, including acdA, fadA, fadB, fadE, fadF, fadG, fadH, fadM, fadN, lcfA and lcfB. Binding of FadR to DNA is specifically inhibited by long chain fatty acyl-CoA compounds of 14-20 carbon atoms in length.

About this Structure

3whc is a 6 chain structure. Full crystallographic information is available from OCA.

Reference

  • Fujihashi M, Nakatani T, Hirooka K, Matsuoka H, Fujita Y, Miki K. Structural characterization of a ligand-bound form of Bacillus subtilis FadR involved in the regulation of fatty acid degradation. Proteins. 2013 Dec 20. doi: 10.1002/prot.24496. PMID:24356978 doi:http://dx.doi.org/10.1002/prot.24496

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