Janus kinase

From Proteopedia

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Template:STRUCTURE 3tjc

Janus kinase (JAK) are nonreceptor tyrosine kinases which transduces cytokine-mediated signals via the JAK-STAT pathway. The JAK-STAT pathway transmits signals through the cell membrane to DNA promoters thus causing transcription. The name JAK is derived from Just Another Kinase. JAK proteins contain 2 phosphate-transfer domains, one with kinase activity using a phosphotyrosine (PTyr) and the other a pseudokinase domain which negatively regulates the kinase domain. JAK contains seven Janus homology domains named JH1-7. JAK family members are JAK1, JAK2, JAK3 and TYK2. JAK1 and TYK2 are involved in signaling by members of type I and type II cytokine receptors .JAK2 is involved in signaling by members of the interferon receptors (type II cytokines). JAK3 is predominantly active in immune cells. JAK3 is activated by cytokines whose receptors contain the common γ chain subunit (interleukin 2,4,7,9,15,21). TYK2 is a component of type I and type III interferon signaling pathways.

Contents 1 3D Structures of Janus kinase 1.1 JAK1 1.2 JAK2 kinase domain 1.3 JAK2 JH1 domain 1.4 JAK2 pseudokinase domain 1.5 JAK3 kinase domain 1.6 TYK2 kinase domain 1.7 TYK2 pseudokinase domain

3D Structures of Janus kinase

Updated on 19-March-2014

JAK1

4e4l, 4e4n, 4e5w, 4ehz, 4ei4, 4fk6, 4i5c, 4k6z – hJAK1 kinase domain + PTyr + inhibitor - human
4k77 – hJAK1 JH1 domain + PTyr + inhibitor
4l00 – hJAK1 pseudokinase domain
4l01 – hJAK1 pseudokinase domain (mutant)

JAK2 kinase domain

4fvp - hJAK2 kinase domain
2b7a, 3fup, 4e6d, 4e6q, 4f08 – hJAK2 kinase domain (mutant) + PTyr + inhibitor
3ugc, 4bbe, 4bbf, 3zmm, 2xa4, 4c61, 4c62 – hJAK2 kinase domain (mutant) + inhibitor
3e62, 3e63, 3e64, 2w1i, 3io7, 3iok, 3kck, 3jy9, 3lpb, 3krr, 3q32, 3tjc, 3tjd, 3rvg, 4aqc, 4e4m, 4f09, 4hge – hJAK2 kinase domain + PTyr + inhibitor
4gl9 – mJAK2 kinase domain + PTyr + inhibitor + suppressor of cytokine signaling 3 + interleukin 6 receptor subunit β - mouse

JAK2 JH1 domain

4gfm, 4gmy, 4iva, 4ivb, 4ivc, 4ivd, 4ji9, 4jia - hJAK2 JH1 domain + PTyr + inhibitor

JAK2 pseudokinase domain

3ugc – hJAK2 pseudokinase domain (mutant)
4fvq, 4fvr – hJAK2 pseudokinase domain (mutant) + ATP

JAK3 kinase domain

1yvj – hJAK3 kinase domain (mutant) + PTyr + staurosporine analog
3lxk, 3lxl – hJAK3 kinase domain (mutant) + PTyr + inhibitor
3pjc – hJAK3 kinase domain + inhibitor
4hvd, 4hvg, 4hvh, 4hvi, 3zc6, 3zep, 4i6q – hJAK3 kinase domain (mutant) + inhibitor

TYK2 kinase domain

3lxn, 3lxp – hTYK2 kinase domain (mutant) + PTyr + inhibitor
3nyx, 3nz0 – hTYK2 kinase domain (mutant) + inhibitor
4e1z, 4e20 – mTYK2 kinase domain (mutant) + inhibitor

TYK2 pseudokinase domain

3zon – hTYK2 pseudokinase domain + inhibitor