4lxj

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Template:STRUCTURE 4lxj

Contents

Saccharomyces cerevisiae lanosterol 14-alpha demethylase with lanosterol bound

Template:ABSTRACT PUBMED 24613931

Function

[CP51_YEAST] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.

About this Structure

4lxj is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Monk BC, Tomasiak TM, Keniya MV, Huschmann FU, Tyndall JD, O'Connell JD 3rd, Cannon RD, McDonald JG, Rodriguez A, Finer-Moore JS, Stroud RM. Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3865-70. doi:, 10.1073/pnas.1324245111. Epub 2014 Feb 3. PMID:24613931 doi:http://dx.doi.org/10.1073/pnas.1324245111

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