4hgc

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Template:STRUCTURE 4hgc

Contents 1 Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at position p1 2 Function 3 About this Structure 4 Reference

Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at position p1

Template:ABSTRACT PUBMED 24598736

Function

[SFTI1_HELAN] Inhibits trypsin, cathepsin G, elastase, chymotrypsin and thrombin. Does not inhibit factor Xa.^[1]

About this Structure

4hgc is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

• Krzywda S, Jaskolski M, Rolka K, Stawikowski MJ. Structure of a proteolytically resistant analogue of (NLys)(5)SFTI-1 in complex with trypsin: evidence for the direct participation of the Ser214 carbonyl group in serine protease-mediated proteolysis. Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):668-75. doi:, 10.1107/S1399004713032252. Epub 2014 Feb 15. PMID:24598736 doi:http://dx.doi.org/10.1107/S1399004713032252

1. ↑ Luckett S, Garcia RS, Barker JJ, Konarev AV, Shewry PR, Clarke AR, Brady RL. High-resolution structure of a potent, cyclic proteinase inhibitor from sunflower seeds. J Mol Biol. 1999 Jul 9;290(2):525-33. PMID:10390350 doi:10.1006/jmbi.1999.2891