6tmn

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Image:6tmn.gif

6tmn, resolution 1.6Å

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STRUCTURES OF TWO THERMOLYSIN-INHIBITOR COMPLEXES THAT DIFFER BY A SINGLE HYDROGEN BOND

Overview

The mode of binding to thermolysin of the ester analog Cbz-GlyP-(O)-Leu-Leu has been determined by x-ray crystallography and shown to be virtually identical (maximum difference 0.2 angstrom) with the corresponding peptide analog Cbz-GlyP-(NH)-Leu-Leu. The two inhibitors provide a matched pair of enzyme-inhibitor complexes that differ by 4.1 kilocalories per mole in intrinsic binding energy but are essentially identical except for the presence or absence of a specific hydrogen bond.

About this Structure

6TMN is a Single protein structure of sequence from [1] with and as ligands. Active as Thermolysin, with EC number 3.4.24.27 Full crystallographic information is available from OCA.

Reference

Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond., Tronrud DE, Holden HM, Matthews BW, Science. 1987 Jan 30;235(4788):571-4. PMID:3810156

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