4ntj
From Proteopedia
Contents |
Structure of the human P2Y12 receptor in complex with an antithrombotic drug
Disease
[P2Y12_HUMAN] Resistance to clopidogrel in myocardial infarction, cerebrovascular accident, oblitering arteriopathy of the lower limbs;P2Y12 defect. The disease is caused by mutations affecting the gene represented in this entry.
Function
[P2Y12_HUMAN] Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation.
About this Structure
4ntj is a 1 chain structure. Full crystallographic information is available from OCA.
Categories: Cherezov, V. | Fenalti, G. | GPCR, GPCR Network. | Gao, Z G. | Han, G W. | Jacobson, K A. | Jiang, H. | Katritch, V. | Kiselev, E. | Lu, W. | Moss, S M. | Muller, C E. | Paoletta, S. | Stevens, R C. | Wu, B. | Yang, H. | Zhang, D. | Zhang, J. | Zhang, K. | Zhang, W. | Zhao, Q. | Zhu, L. | Antithrombotic drug | Gpcr | Gpcr network | Human p2y12 receptor | Lipidic cubic phase | Membrane | Membrane protein | Psi-biology | Signaling protein | Structural genomic
