Outer surface protein

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 2af5

Outer surface proteins (Osp) are produced by the bacteria Borrelia burgdorferi which causes Lyme disease. OspA and OspB are upregulated when the bacteria enter the tick. OspA contributes to the colonization of the gut by the bacteria. OspC is a major antigen on the surface of the Lyme disease spirochetes when it is being transmitted to humans. For more details see:
OspA -

• OspA
  
• G09SecL04Tpc2
  
• G1SecL05
  

OspB -

• Outer surface protein B (OspB) of the Lyme disease spirochete bacterium
  
• G15SecL05Tpc3
  
• G14secL04Tpc3
  

OspC -

• OspC and Binding
  
• SB2013 L08gr01
  
• G18secL03Tpc4.

OxpA, OspB and OspC -

• Highlighted Proteins of Lyme Disease
  

Contents 1 3D structures of outer surface protein 1.1 OspA 1.2 OspB 1.3 OspC 1.4 OspE

3D structures of outer surface protein

Updated on 01-April-2014

OspA

1osp, 1fj1 – OspA (mutant) + antibody – Borrelia burgdorferi
2af5, 2fkg, 2fkj, 2hkd, 2oyb – OspA
2g8c, 2i5z, 2ol6, 2ol7, 2ol8, 2oy1, 2i5v, 2oy5, 2oy7, 2oy8, 2pi3, 3aum, 3cka, 3ckf, 3ckg, 3ec5, 3eex - OspA (mutant)

OspB

1p4p – OspB C terminal
1rjl - OspB+ antibody
2yn7 – OspB

OspC

1ggq, 1g5z – OspC
1f1m – OspC (mutant)

OspE

2m4f – OspE – NMR
4j38 – OspE + complement factor H