This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Pantothenate kinase
From Proteopedia
Pantothenate kinase (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis. PanK is regulated by feedback inhibition by CoA and its thioesters. Three types of PanK are known. PanK I found in bacteria; PanK II found mostly in eukaryotes; PanK III found in bacteria and known as CoaX.
Contents |
3D structures of pantothenate kinase
Updated on 02-April-2014
1esm – EcPanK + CoA – Escherichia coli
1esn - EcPanK + ANP
1sq5 - EcPanK + ADP + PAU
3tqc - PanK – Coxiella burnetii
PanK I binary complex
2ges, 2get, 2zs7, 2geu, 2gev - MtPanK + CoA derivative – Mycobacterium tuberculosis
2zs8, 2zsb - MtPanK + ADP
3af1 - MtPanK + GDP
3af2 - MtPanK + AMPPCP
3af4 - MtPanK + GMPPCP
2zsd - MtPanK + CoA
3avo - MtPanK + PAU
3avp, 3avq - MtPanK + PAU derivative
4bfs, 4bft, 4bfu, 4bfv, 4bfw, 4bfx - MtPanK + triazole inhibitor
4bfy, 4bfz - MtPanK + biaryl inhibitor
PanK I ternary complex
2zs9 - MtPanK + ADP + PAU
2zse - MtPanK + AMPPCP + PAU
3af3 - MtPanK + GMPPCP + PAU
2zsf - MtPanK + ADP + ATP
2zsa - MtPanK + ADP + PPT
3aez - MtPanK + GDP + PPT
3af0 - MtPanK + GDP + PAU
4f7w, 4ne2 – KpPanK + ADP + pantothenamide derivative – Klebsiella pneumonia
4gi7 – KpPanK + ADP + pantothenate analog
PanK II
2ews - SaPanK + ANP – Staphylococcus aureus
4nb4 - SaPanK + ADP + pantothenamide
PanK III
2gtd - TmPanK – Thermotoga maritima
2f9t – PaPanK – Pseudomonas aeruginosa
2h3g - PanK – Bacillus anthracis
3djc - PanK – Legionella pneumophila
4o8k - BtPanK – Burkholderia thailandensis
PanK III binary complex
2f9w - PaPanK + PAU
3bex - TmPanK + PAU
3bf3 - TmPanK + PPT
PanK III ternary complex
3bf1 - TmPanK + ADP + PAU
4o5f - BtPanK + ADP + PAU
Human PanK
2i7n, 3smp - hPanK 1 α + CoA - human
2i7p, 3mk6 - hPanK 3 + CoA
3sms – hPanK 3 + PAU analog
