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4ka6

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Template:STRUCTURE 4ka6

Contents

Structure of D141A variant of B. pseudomallei KatG complexed with INH

Template:ABSTRACT PUBMED 24568093

Function

[KATG_BURPS] Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Displays also NADH oxidase, isoniazid hydrazine lyase and isonicotinoyl-NAD synthase activity.[1]

About this Structure

4ka6 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Vidossich P, Loewen PC, Carpena X, Fiorin G, Fita I, Rovira C. Binding of the Antitubercular Pro-Drug Isoniazid in the Heme Access Channel of Catalase-Peroxidase (KatG). A Combined Structural and Metadynamics Investigation. J Phys Chem B. 2014 Mar 20;118(11):2924-31. doi: 10.1021/jp4123425. Epub 2014 Mar, 7. PMID:24568093 doi:http://dx.doi.org/10.1021/jp4123425
  1. ↑ Singh R, Wiseman B, Deemagarn T, Donald LJ, Duckworth HW, Carpena X, Fita I, Loewen PC. Catalase-peroxidases (KatG) exhibit NADH oxidase activity. J Biol Chem. 2004 Oct 8;279(41):43098-106. Epub 2004 Jul 26. PMID:15280362 doi:10.1074/jbc.M406374200

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