4oj8

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Template:STRUCTURE 4oj8

Contents

Crystal structure of carbapenem synthase in complex with (3S,5S)-carbapenam

Template:ABSTRACT PUBMED 24604200

Function

[CARC_PECCC] Catalyzes the Fe(2+) and alpha-ketoglutarate-dependent conversion of (3S,5S)-carbapenam to (5R)-carbapenem, an essential step in carbapenem antibiotic biosynthesis.[1] [2] [3] [4]

About this Structure

4oj8 is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

  • Chang WC, Guo Y, Wang C, Butch SE, Rosenzweig AC, Boal AK, Krebs C, Bollinger JM Jr. Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics. Science. 2014 Mar 7;343(6175):1140-4. doi: 10.1126/science.1248000. PMID:24604200 doi:http://dx.doi.org/10.1126/science.1248000
  1. ↑ McGowan SJ, Sebaihia M, O'Leary S, Hardie KR, Williams P, Stewart GS, Bycroft BW, Salmond GP. Analysis of the carbapenem gene cluster of Erwinia carotovora: definition of the antibiotic biosynthetic genes and evidence for a novel beta-lactam resistance mechanism. Mol Microbiol. 1997 Nov;26(3):545-56. PMID:9402024
  2. ↑ Stapon A, Li R, Townsend CA. Carbapenem biosynthesis: confirmation of stereochemical assignments and the role of CarC in the ring stereoinversion process from L-proline. J Am Chem Soc. 2003 Jul 16;125(28):8486-93. PMID:12848554 doi:http://dx.doi.org/10.1021/ja034248a
  3. ↑ Sleeman MC, Smith P, Kellam B, Chhabra SR, Bycroft BW, Schofield CJ. Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC). Chembiochem. 2004 Jun 7;5(6):879-82. PMID:15174175 doi:http://dx.doi.org/10.1002/cbic.200300908
  4. ↑ Clifton IJ, Doan LX, Sleeman MC, Topf M, Suzuki H, Wilmouth RC, Schofield CJ. Crystal structure of carbapenem synthase (CarC). J Biol Chem. 2003 Jun 6;278(23):20843-50. Epub 2003 Feb 28. PMID:12611886 doi:10.1074/jbc.M213054200

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