4bvn
From Proteopedia
Contents |
Ultra-thermostable beta1-adrenoceptor with cyanopindolol bound
Template:ABSTRACT PUBMED 24663151
Function
[ADRB1_MELGA] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
About this Structure
4bvn is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Miller-Gallacher JL, Nehme R, Warne T, Edwards PC, Schertler GF, Leslie AG, Tate CG. The 2.1 A Resolution Structure of Cyanopindolol-Bound beta1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor. PLoS One. 2014 Mar 24;9(3):e92727. doi: 10.1371/journal.pone.0092727. eCollection, 2014. PMID:24663151 doi:http://dx.doi.org/10.1371/journal.pone.0092727