3wgt

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Template:STRUCTURE 3wgt

Contents

Crystal structure of D-amino acid oxidase mutant

Template:ABSTRACT PUBMED 24644036

Function

[OXDA_PIG] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.

About this Structure

3wgt is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Yasukawa K, Nakano S, Asano Y. Tailoring D-Amino Acid Oxidase from the Pig Kidney to R-Stereoselective Amine Oxidase and its Use in the Deracemization of alpha-Methylbenzylamine. Angew Chem Int Ed Engl. 2014 Mar 18. doi: 10.1002/anie.201308812. PMID:24644036 doi:http://dx.doi.org/10.1002/anie.201308812

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