Peroxiredoxin
From Proteopedia
Peroxiredoxin (Prx) is an antioxidant enzyme. In the Prxs the active-site Cys is oxidized to sulfenic acid byperoxide. The Prxs are divided into typical 2-Cys Prx, atypical 2-Cys Prx and 1-Cys Prx. Prx 5 is expressed in mammalian tissue. The images at the left and at the right correspond to one representative Prx, i.e. the crystal structure of Peroxiredoxin from rat (1qq2).
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3D Structures of Peroxiredoxin
Updated on 02-April-2014
1qq2 – r2Cys-Prx – rat
2c0d – Pf2Cys-Prx – Plasmodium falciparum
1xiy – Pf1Cys-Prx
1xcc, 2h01, 3tb2 - 1Cys-Prx – Plasmodium yoelii
2i81 - 2Cys-Prx – Plasmodium vivax
1qmv - h2Cys-Prx – human
2a4v – yPrx dot5 C-terminal (mutant) – yeast
3cmi – yPrx hyr1
4g2e – Prx – Sulfolobus tokodaii
3sbc – yPrx Tsa1 (mutant)
1uul - 2Cys-Prx – Trypanosoma cruzi
1we0 – Prx – Amphibacillus xylanus
2cv4, 2cx3, 2cx4 – Prx – Aeropyrum pernix
3drn – SsPrx – Sulfolobus solfataricus
3hjp – SsPrx (mutant)
3ixr – Prx PRXQ (mutant) – Xylella fastidiosa
Peroxiredoxin 1
2rii, 3hy2 – hPrx 1 (mutant)+sulfiredoxin 1
2z9s – rPrx 1 (mutant)
4kw6, 4fh8 – Prx 1 – Ancylostoma ceylanicum
3zl5 - mPrx 1 (mutant) – mouse
Peroxiredoxin 2
1tp9 – Prx II – Populus trichocarpa
2pwj – Prx II – garden pea
4dsq, 4dsr, 4h86 – yPrx II
4dss – yPrx II (mutant) + thioredoxin II
Peroxiredoxin 3
1zye – Prx III (mutant) – bovine
Peroxiredoxin 4
3tjf, 3tjg, 3tjj, 3tjk, 3tkr - hPrx 4 (mutant)
3qpm – Prx 4 – Larimichtys crocea
2pn8, 3tjb, 3tkp, 3tkq, 3tks – hPrx 4
3vwu, 3vwv - mPrx 4 (mutant)
Peroxiredoxin 5
1urm – hPrx 5 (mutant) – human
2vl2, 2vl3, 2vl9, 1h4o, 1hd2, 1oc3 – hPrx 5
3mng – hPrx 5+DTT
2wfc – lPrx 5 - lugworm
2xhf – Prx 5 – Alvinella pompejana
Peroxiredoxin 6
2v2g – lPrx 6
2v32, 2v41 – lPrx 6 (mutant)
