4k26

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Template:STRUCTURE 4k26

Contents 1 4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 -HSD1 inhibitors for the treatment of diabetes 2 Function 3 About this Structure 4 Reference

4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 -HSD1 inhibitors for the treatment of diabetes

Template:ABSTRACT PUBMED 23845218

Function

[DHI1_MOUSE] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.

About this Structure

4k26 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

• Bohme T, Engel CK, Farjot G, Gussregen S, Haack T, Tschank G, Ritter K. 1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11ss-HSD1 inhibitors for the treatment of diabetes. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4685-91. doi:, 10.1016/j.bmcl.2013.05.102. Epub 2013 Jun 11. PMID:23845218 doi:http://dx.doi.org/10.1016/j.bmcl.2013.05.102