2mjn

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Template:STRUCTURE 2mjn

Contents 1 Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1 2 Function 3 About this Structure 4 Reference

Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1

Template:ABSTRACT PUBMED 24682828

Function

[TIA1_HUMAN] Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.

About this Structure

2mjn is a 1 chain structure. Full experimental information is available from OCA.

Reference

• Wang I, Hennig J, Jagtap PK, Sonntag M, Valcarcel J, Sattler M. Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1. Nucleic Acids Res. 2014 Mar 25. PMID:24682828 doi:http://dx.doi.org/10.1093/nar/gku193