This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4n3t
From Proteopedia
Contents |
Candida albicans Superoxide Dismutase 5 (SOD5), Cu(I)
Function
[SOD5_CANAL] Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent.[1] [2] [3]
About this Structure
4n3t is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Martchenko M, Alarco AM, Harcus D, Whiteway M. Superoxide dismutases in Candida albicans: transcriptional regulation and functional characterization of the hyphal-induced SOD5 gene. Mol Biol Cell. 2004 Feb;15(2):456-67. Epub 2003 Nov 14. PMID:14617819 doi:http://dx.doi.org/10.1091/mbc.E03-03-0179
- ↑ Frohner IE, Bourgeois C, Yatsyk K, Majer O, Kuchler K. Candida albicans cell surface superoxide dismutases degrade host-derived reactive oxygen species to escape innate immune surveillance. Mol Microbiol. 2009 Jan;71(1):240-52. doi: 10.1111/j.1365-2958.2008.06528.x. Epub, 2008 Nov 4. PMID:19019164 doi:http://dx.doi.org/10.1111/j.1365-2958.2008.06528.x
- ↑ Bink A, Vandenbosch D, Coenye T, Nelis H, Cammue BP, Thevissen K. Superoxide dismutases are involved in Candida albicans biofilm persistence against miconazole. Antimicrob Agents Chemother. 2011 Sep;55(9):4033-7. doi: 10.1128/AAC.00280-11., Epub 2011 Jul 11. PMID:21746956 doi:http://dx.doi.org/10.1128/AAC.00280-11
