1a37

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Template:STRUCTURE 1a37

Contents

14-3-3 PROTEIN ZETA BOUND TO PS-RAF259 PEPTIDE

Template:ABSTRACT PUBMED 9632691

Function

[1433Z_BOVIN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Activates the ADP-ribosyltransferase (exoS) activity of bacterial origin.[1]

About this Structure

1a37 is a 4 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

  • Petosa C, Masters SC, Bankston LA, Pohl J, Wang B, Fu H, Liddington RC. 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove. J Biol Chem. 1998 Jun 26;273(26):16305-10. PMID:9632691
  1. ↑ Tanji M, Horwitz R, Rosenfeld G, Waymire JC. Activation of protein kinase C by purified bovine brain 14-3-3: comparison with tyrosine hydroxylase activation. J Neurochem. 1994 Nov;63(5):1908-16. PMID:7931346

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