1a3c

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Template:STRUCTURE 1a3c

Contents

PYRR, THE BACILLUS SUBTILIS PYRIMIDINE BIOSYNTHETIC OPERON REPRESSOR, DIMERIC FORM

Template:ABSTRACT PUBMED 9551555

Function

[PYRR_BACSU] Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.[HAMAP-Rule:MF_01219] Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.[HAMAP-Rule:MF_01219]

About this Structure

1a3c is a 1 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

  • Tomchick DR, Turner RJ, Switzer RL, Smith JL. Adaptation of an enzyme to regulatory function: structure of Bacillus subtilis PyrR, a pyr RNA-binding attenuation protein and uracil phosphoribosyltransferase. Structure. 1998 Mar 15;6(3):337-50. PMID:9551555

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