1cm9

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Template:STRUCTURE 1cm9

Contents

CRYSTAL STRUCTURE OF VIRAL MACROPHAGE INFLAMMATORY PROTEIN-II

Template:ABSTRACT PUBMED 11041848

Function

[VMI2_HHV8] Blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors. May form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.

About this Structure

1cm9 is a 2 chain structure with sequence from Human herpesvirus 8. Full crystallographic information is available from OCA.

Reference

  • Fernandez EJ, Wilken J, Thompson DA, Peiper SC, Lolis E. Comparison of the structure of vMIP-II with eotaxin-1, RANTES, and MCP-3 suggests a unique mechanism for CCR3 activation. Biochemistry. 2000 Oct 24;39(42):12837-44. PMID:11041848

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